From Net Confusion to Net Realization - Bursting the GtN Bubble
Gain end-to-end visibility from list to net across rebates, 340B, chargebacks, and assistance. Apply a GtN playbook that solves governance, analytics, and precision contracting. Cut leakage, stabilize forecasts, and grow margin without zero issues.
GtN Problems We Solve for You
Stop GtN complexity from eroding margins & tying-up cash. Practus delivers clarity, control, and enhanced financial performance for Pharma CFOs
Lack of Clarity
Navigating the maze of chargebacks, rebates, fees, and accruals feels impossible.
Revenue Erosion
Inaccurate accruals, missed rebate validations, and unresolved chargebacks drain your bottom line.
Inaccurate Forecasting
Inaccurate GTN forecasting leads to financial surprises and missed targets.
Time-Consuming Processes
Manual data entry and reconciliation are slow, error-prone, and inefficient.
Drive Measurable Financial Improvements
Unlock your full financial potential with our data-driven solutions.
15-30%+
Improved GtN Accuracy
Reduce accrual vs. actual variance, leading to more predictable forecasting and fewer financial surprises.
5-10%+
Reduced Revenue Leakage
Identify and recover revenue previously lost to rebate errors, unvalidated deductions and incorrect chargebacks.
8-15 Days
Accelerated Cash Flow
Lower Days Sales Outstanding (DSO) through effective AR cleanup and streamlined dispute resolution.
Up to 30%
Reduced Dispute Volumes
Reduced Chargeback and rebate disputes volume, lowering administrative burden and compliance risk.
25%+
Faster Insights & Reporting
Cut down reporting and analysis time for GtN/AR, enabling quicker, data-driven decisions.
20-35%
Increased Team Efficiency
Reduce manual effort on reconciliation and disputes, freeing up your team for higher-value activities.
Growth: List vs Net Price
List growth slowed from +13.5% (2014) to +2.3% (2024), while net moved from persistent declines to ~+0.1% (2024). The list–net spread narrowed from 8.4 pp (2023) to 2.2 pp (2024)—a meaningful compression.
Indexed Price Growth (2014 = 100)
Divergence - All Brands
A seventh straight net decline in 2024
Follow the GtN Dollar: The Where and the What
Rebates dominate, 340B surges - Don't risk 80% of your revenue
The Real Mix Behind Net
Industry-wide benchmark mix (GtN)
Therapeutic Class Dynamics
Discount distribution by class, highlighting payer leverage
GtN and the Innovation Squeeze
The growth in the GtN bubble from 2023-2024 is equivalent to the cost of developing 4 new drugs, at $2.6B for each new drug.
340B Concentration
Innovation-Heavy Classes (2021)
| Rank | Therapeutic Area | Spend ($B) | Share |
|---|---|---|---|
| 1 | Cancer Drugs | $18.1 | 39.0% |
| 2 | Immunosuppressants | $6.2 | 13.4% |
| 3 | Anti-Infective Agents | $6.6 | 14.2% |
| — | All Other | $15.5 | 33.4% |
| Top 3 Subtotal | $30.9 | 66.6% | |
| Total | $46.4 | 100.0% | |
Innovation Squeeze Index
GTN ÷ PhRMA R&D
Source: Tufts Center for the Study of Drug Development - Cost of Developing New Drugs, accessed September 17, 2025
340B is Exploding and Destroying Your Margins
340B Purchases Near $80B in 2024—Up 3.5× Since 2017
340B Discounted Purchases (US$B)
Sources: HRSA and DCI, 2024
Let's Solve Your Gross-to-Net Problems
Reduce leakage. Stabilize forecasts. Pass audits.
Revenue erosion
$356B lost to rebates/discounts/fees
GTN / AR Clean-up
Impact 5 · TtV 0–2 months
GTN Process Diagnostics
Impact 4 · TtV 1–3 months
GTN Process Transformation
Impact 4 · TtV 3–6 months
Forecasting volatility
Accrual errors & surprise true-ups
GTN Process Diagnostics
Impact 5 · TtV 1–3 months
GTN Process Transformation
Impact 5 · TtV 3–6 months
Aged AR & DSO
Unapplied cash, duplicates, weak disputes
GTN / AR Clean-up
Impact 5 · TtV 0–2 months
Compliance exposure
Medicaid/340B/IRA errors → penalties
GTN / AR Clean-up
Impact 4 · TtV 0–2 months
GTN Process Diagnostics
Impact 4 · TtV 1–3 months
Operational silos
Finance, Sales Ops, Contracts, 3PL
GTN Process Diagnostics
Impact 3 · TtV 1–3 months
GTN Process Transformation
Impact 3 · TtV 3–6 months
Problems
GTN / AR Clean-up
GTN Process Diagnostics
GTN Process Transformation
Revenue erosion
$356B lost to rebates/discounts/fees
Forecasting volatility
Accrual errors & surprise true-ups
Aged AR & DSO
Unapplied cash, duplicates, weak disputes
Compliance exposure
Medicaid/340B/IRA errors → penalties
Operational silos
Finance, Sales Ops, Contracts, 3PL
Time-to-Value:
Impact:
| Problem | GTN / AR Clean-up | GTN Process Diagnostics | GTN Process Transformation |
|---|---|---|---|
| Revenue erosion | Impact 5 · TtV 0–2 months | Impact 4 · TtV 1–3 months | Impact 4 · TtV 3–6 months |
| Forecasting volatility | — | Impact 5 · TtV 1–3 months | Impact 5 · TtV 3–6 months |
| Aged AR & DSO | Impact 5 · TtV 0–2 months | — | — |
| Compliance exposure | Impact 4 · TtV 0–2 months | Impact 4 · TtV 1–3 months | — |
| Operational silos | — | Impact 3 · TtV 1–3 months | Impact 3 · TtV 3–6 months |
GTN / AR Clean-up
Transaction triage
Evidence & reconciliation
Controlled resolution
GTN Process Diagnostics
As-Is mapping
Data & doc review
To-Be + roadmap
GTN Process Transformation
Data lake & feeds
Dashboards & alerts
Run & improve
What Our Clients Say
Real stories from leaders we've empowered.
"This service has completely transformed our GtN process. The clarity and control we've gained are unparalleled. We've seen a 5x ROI in the first six months alone."
John Doe
CEO, Acme Inc.
Client Problem
- Reduce revenue leakage from invalid chargeback claims.
- Improve the speed and accuracy of claim validation.
- Enhance visibility into claim status and root causes.
Practus' Role
- Implemented an automated claim validation engine.
- Developed a centralized dashboard for real-time tracking.
- Provided a dedicated team for exception handling and dispute resolution.
Impact Delivered
95%
up from 60%
72 hours
down from 2 weeks
"The diagnostics were a game-changer. We identified revenue leakage points we never knew existed and have since recovered millions in unauthorized deductions. I can't recommend them enough."
Jane Smith
CFO, Stark Industries
Impact Delivered
99.8%
up from 85%
100%
fully prepared for HRSA audits
Client Problem
- Ensure full compliance with all HRSA regulations.
- Maximize legitimate 340B savings.
- Reduce the administrative burden of program management.
Practus' Role
- Conducted a comprehensive audit of existing 340B processes.
- Implemented a real-time compliance monitoring system.
- Provided ongoing support and training for staff.
Turn Data into Insights in 5-Steps
See our data-driven process in action.
Why Practus?
The tools and expertise you need to lead your industry.
AI-Powered Insights
Leverage machine learning to uncover hidden patterns and predict future trends with unparalleled accuracy.
Interactive Dashboards
Visualize your data with stunning, real-time dashboards that are both powerful and easy to use.
Strategic Consulting
Partner with our team of data strategists to turn insights into impactful business actions.
Predictive Analytics
Forecast future outcomes and identify risks and opportunities with our advanced predictive models.
Performance Tracking
Monitor your KPIs in real-time to make data-driven decisions that accelerate growth.
Bespoke Solutions
We build custom analytics solutions tailored to your unique challenges and industry landscape.
Ready to Disrupt?
Let's talk about how we can transform your data into your most valuable asset. Fill out the form to schedule a free consultation with one of our experts.
Email: contact@practus.com
Phone: (555) 123-4567
Request a Consultation
Get in touch with our team.